Lysosomal phospholipase a2 lpla2
Web1 ian. 2024 · Abstract Phospholipase A (PLA) hydrolyzes the acyl ester bonds to release fatty acids from membrane phospholipids. PLA comprises multiple families and subfamilies of enzymes that have distinct... WebAnti Lysophospholipase 3 antibody, Anti LYPLA 3 antibody, Anti DKFZp564A0122 antibody, Anti Lysosomal phospholipase A2 antibody, Anti UNQ341/PRO540. antibody, Anti GXVPLA2 ... Anti 1-O-acylceramide synthase antibody, Anti Phospholipase A2 antibody, Anti LPLA2 antibody, Anti LCAT-like lysophospholipase antibody, Anti group XV …
Lysosomal phospholipase a2 lpla2
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Web1 oct. 2024 · Both enzymes belong to the αβ-hydrolase superfamily, have a conserved catalytic triad consisting of Ser/Asp/His and show a dual enzyme activity, phospholipase A2 and transacylase [11]. LPLA2 catalyzes the esterification of lipophilic alcohols such as short chain ceramides in the presence of glycerophospholipids under acidic conditions [13].
WebPLA2 plays a key role in both phospholipid remodeling and signal transduction as the PLA2 products are important second messengers that play relevant roles in different signal transduction pathways. PLA2G6 encodes a calcium-independent group VI phospholipase A2, which localizes to the neuronal mitochondria and endosomal and lysosomal … Web2 aug. 2024 · Lysosomal phospholipase A2 (PLA2G15) is a ubiquitous enzyme uniquely characterized by a subcellular localization to the lysosome and late endosome. PLA2G15 has an acidic pH optimum, is calcium independent, and acts as a transacylase in the presence of N-acetyl-sphingosine as an acceptor.
WebLYSOSOMAL PHOSPHOLIPASE A2; LPLA2 HGNC Approved Gene Symbol: PLA2G15 Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:68,245,373-68,261,058 (from NCBI) TEXT Cloning and Expression WebLysosomal phospholipase A2 contributes to the biosynthesis of the atypical late endosome lipid bis(monoacylglycero)phosphate.
Web3 mai 2024 · Lysosomal phospholipase A2 (LPLA2) is characterized by broad substrate recognition, peak activity at acidic pH, and the transacylation of lipophilic alcohols, especially N-acetyl-sphingosine....
WebEchelon’s Lysosomal Phospholipase A2 (LPLA2) Activity Assay is a homogenous assay designed to detect activity from biological and purified sources of LPLA2. This in vitro, … arti tato keberuntunganWeb4 iun. 2024 · To evaluate the key events in hepatotoxicity associated with lysosomal phospholipase A2 (LPLA2) inhibition by cationic amphiphilic drugs (CADs), LPLA2 inhibition assays and phospholipid accumulation assays were performed in HepG2 cells. Additionally, to suggest the integrative molecular mechanisms of hepatotoxicity by CADs, … arti tato malaikat bersayapWebLysosomal phospholipase A(2) (Lpla2) is highly expressed in alveolar macrophages and may mediate the phospholipid metabolism of surfactant. Studies on the properties of this phospholipase are consistent with the presence of both phospholipase A(1) and phospholipase A(2) activities. ... Lysosomal phospholipase A2 (LPLA2) … band jaringan telkomselWebIt also showed marked phospholipase A2 activity under acidic conditions. Mutation of serine to alanine in the lipase motif resulted in an inactive protein. Deglycosylation … arti tato kupu kupu di dadaWebMore Information; Category: Primary antibodies: Catalog Number: orb954999: Species/Host: Rabbit: Clonality: Polyclonal: Tested applications: ELISA, ICC, IF, IHC-Fr ... arti tato kupu kupu di punggungWeb15 mai 2024 · Lysosomal phospholipase A2 (LPLA2) is a key enzyme involved in the homeostasis of cellular phospholipids. Recently, LPLA2 was reported to preferentially … band japan rockWebPolysorbate degrading activity was enriched from Chinese hamster ovary media leading to the identification of group XV lysosomal phospholipase A2 isomer X1 (LPLA2) by … b and j auto sales auburn ky