Mechanistic understanding of human slfn11
WebMy Research and Language Selection Sign into My Research Create My Research Account English; Help and support. Support Center Find answers to questions about products, … WebAug 29, 2024 · SLFN11 is expressed in monocytes and monocyte-derived dendritic cells [ 51] and is upregulated in monocyte-derived dendritic cells upon exposure to IFN-α, LPS, or rhinovirus [ 51 ]. Similar to SLFN5, SLFN11 has been identified as part of the NOTCH1 nuclear interactome [ 53 ].
Mechanistic understanding of human slfn11
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WebSLFN11 has been identified as a predictive biomarker in cancer, as its expression correlates with a beneficial response to DNA damage inducing anticancer drugs. However, the … WebMechanistic understanding of human SLFN11 Felix J. Metzner, Simon J. Wenzl, Michael Kugler, Stefan Krebs, Karl-Peter Hopfner, Katja Lammens; Affiliations Felix J. Metzner …
WebDec 9, 2015 · High expression levels of SLFN11 correlate with the sensitivity of human cancer cells to DNA-damaging agents. However, little is known about the underlying mechanism. Here, we show that SLFN11 interacts directly with RPA1 and is recruited to sites of DNA damage in an RPA1-dependent manner. WebSLFN11 has been identified as a predictive biomarker in cancer, as its expression correlates with a beneficial response to DNA damage inducing anticancer drugs. However, the …
WebSchlafen 11 (SLFN11) is an interferon-inducible antiviral restriction factor with tRNA endoribonuclease and DNA binding functions. It is recruited to stalled replication forks in response to replication stress and inhibits replication of certain viruses such as the human immunodeficiency virus 1 (HIV-1) by modulating the tRNA pool. SLFN11 has been … WebDec 9, 2015 · Understanding the molecular mechanisms behind SLFN11 involvement in DNA damage response will help clarify its clinical importance and may pave the way for human cancer therapies. In this study, we have provided several lines of evidence to show that SLFN11 is a novel endogenous inhibitor of DNA damage response in cancer cells …
WebDec 18, 2024 · For the aforementioned agents, and in multiple cancer cell line panels, the presence of SLFN11 has been shown to correlate with sensitivity, whereas the low or absent expression has been...
WebJan 15, 2024 · Conclusions: SLFN11 is a relevant predictive biomarker of sensitivity to PARP inhibitor monotherapy in SCLC and we identify combinatorial therapy with TMZ as a particularly promising therapeutic strategy that warrants further clinical investigation. Clin Cancer Res; 23 (2); 523–35. ©2016 AACR. Translational Relevance seismic for outlookWebMar 31, 2024 · Mechanistic understanding of human SLFN11. Metzner, F.J. , Wenzl, S.J. , Kugler, M. , Krebs, S. , Hopfner, K.P. , Lammens, K. (2024) Nat Commun 13: 5464-5464 … seismic finsbury squareWebFeb 28, 2024 · Methods. Transcriptome analysis was performed in human HCC tissues with or without response to ICIs. A humanized orthotopic HCC mouse model and a co-culture system were constructed, and cytometry by time-of-flight technology was used to explore the function and mechanism of SLFN11 in the immune context of HCC. seismic faults in turkeyWebFeb 3, 2024 · SLFN11-expressing cancer cells are consistently hypersensitive to a broad range of chemotherapeutic drugs targeting DNA replication, including topoisomerase inhibitors, alkylating agents, DNA synthesis, and poly (ADP-ribose) polymerase (PARP) inhibitors compared to SLFN11-deficient cancer cells, which are chemoresistant ( 1, 2, 4, 8 … seismic force distributionWebApr 14, 2024 · Pretoria, Republic of South Africa In furtherance of the joint declaration made by the two principal regional human rights bodies on 27 March 2024, to strengthen and institutionalize their strategic cooperation, including by signing a Memorandum of Understanding (MoU) and developing a roadmap of joint activities, delegations of the … seismic faults in southern californiaWebRecently, the Schlafen (SLFN) proteins have been identified as a novel interferon-stimulated family with antiviral properties. In this study, we reported that SLFN11 inhibited prototype foamy virus (PFV) replication. Over-expression of human SLFN11 reduced viral production, while knockdown of SLFN11 … seismic evidence for internal earth structureWebSep 17, 2024 · SLFN11 has been identified as a predictive biomarker in cancer, as its expression correlates with a beneficial response to DNA damage inducing anticancer … seismic floor anchors